In this regard, a novel risk stratification system for MM, known as the Modified Risk Staging (MRS) system, was introduced by Farswan et al. This system leverages machine learning (ML) and six basic laboratory parameters: albumin, β2-microglobulin (β2M), calcium, eGFR, hemoglobin, and age. The gene discussed is HLA-G; the disease is Miyoshi myopathy.