MYOM2 and Miyoshi myopathy: The primary traditional techniques to detect these biomarkers include BM biopsy, serum analysis, 24 h urine analysis, metaphase karyotyping, fluorescence in situ hybridization (FISH), imaging, assessment of monoclonal protein (M protein), identification of abnormal immunoglobulins, measurement of free light chains in the serum and urine of MM patients, as well as detection of chromosomal abnormalities and osteolytic bone lesions [13,20].