GWASs have identified many single-nucleotide polymorphisms associated with breast cancer in intron 2 of FGFR2 [14,15,17,47], and it has been hypothesised that the acetylation of the histones may affect access to the sites, possibly regulating downstream splicing sites, and generate the FGFR2 IIIc isoforms [40,48]. This evidence concerns the gene FGFR2 and breast carcinoma.