Similarly, when tumours were HER2-negative (HER2: 0 or 1+), or equivocal (HER2: 2+), the FGFR2 expression levels were similar, but the levels were significantly lower in HER2-positive (2+ with FISH or 3+) tumours (Figure 4B). This evidence concerns the gene FGFR2 and neoplasm.