It was shown that the combination of aerobic exercise and Spirulina polysaccharide (SP) supplementation significantly enhanced learning and memory ability in T2DM rats, and this improvement may be related to better regulation of the expression of proteins related to the p75NTR signaling pathway, which may inhibit apoptosis in the hippocampal region of T2DM rats [81]. The gene discussed is NGFR; the disease is type 2 diabetes mellitus.