KEAP1 and pancreatic ductal adenocarcinoma: For example, in pancreatic ductal adenocarcinoma, CPT1B affects the expression and silencing of genes related to ferroptosis downstream of KEAP1 through protein interaction with KEAP1, thereby inhibiting the occurrence and development of ferroptosis, and the combined use of gemcitabine and knockdown of CPT1B can significantly enhance the therapeutic effect of the chemotherapy drug gemcitabine [99].