Recent studies have shown that primary breast tumors or high-fat diet-induced alveolar type 2 (AT2) cells are able to secrete palmitate, and the secreted palmitate can be used by cancer cells to acetylate nuclear factor κB (NF-κB)/p65 for providing pre-metastatic ecological niches for breast cancer lung metastasis through CPT1A and lysine acetyltransferase 2a (KAT2a) [72]. This evidence concerns the gene KAT2A and breast neoplasm.