In neurofibromas, it was found that p53 is also an upstream regulator of CPT1C that can modulate the metabolic network of cancer cells by influencing changes in its expression level, and in vivo experiments have shown that in CPT1C-knockout mouse tumor models, the rate of tumor growth is relatively retarded, as well as the number of days of survival being significantly increased [112]. The gene discussed is TP53; the disease is neoplasm.