Interestingly, however, in contrast to the previous studies, CPT1A expression was low in chronic myeloid leukemia, with expression lower than 50-fold of normal, and its expression increased after treatment with tyrosine kinase inhibitors, but the detailed reasons and mechanisms of low expression of CPT1A in chronic myeloid leukemia are still unclear [88,89]. This evidence concerns the gene CPT1A and chronic myelogenous leukemia, BCR-ABL1 positive.