IDH2 and central nervous system cancer: To this end, treatment with PARP inhibitors has been shown to abolish ZMYND8 recruitment in cultured cells [124], and the knockdown of ZMYND8 in IDH mutant patient-derived cultured glioma cells resulted in increased sensitivity to radiotherapy as well as significant phosphorylation of ATM and γH2AX activation in response to ionizing radiation [122].