T2-FLAIR MRI sequences enhance the contrast between gray matter and white matter to improve the visibility of lesions [231], and the use of T2-FLAIR mismatch for detecting IDH mutant gliomas is based on T2 complete (or mostly complete) homogeneous hyperintense signal and attenuation of FLAIR signal intensity with a bright peripheral rim [232,233]. The gene discussed is IDH2; the disease is glioma.