STAT3 and colorectal carcinoma: Additionally, after adding Stattic to inhibit the JAK/STAT3 pathway, we observed the inhibition of the angiogenic effects of CRC-EVs on HUVECs, including proliferation (Figure 5C,D and Figures S3 and S4), migration (Figure 5E–G and Figures S5–S7), and tube formation (Figure 5H and Figure S8).