Effector immune cells NKs and CTLs accumulate via the CXCR3-CXCL9/10/11 axis [232];CAF-driven down-regulation of CXCR3 in pancreatic tumor cultures inhibits T cell tumor infiltration towards CXCL10 [233]; M2-derived TGF-β inhibits CTL surface expression of CXCR3 and trafficking in a murine model of colorectal cancer [234]. This evidence concerns the gene TGFB1 and neoplasm.