The CXCL8-CXCR1/2 axis is upregulated in several cancers, where the secretion of its ligand by tumor-associated epithelial cells, macrophages, or endothelial cells is responsible for the recruitment of N2 TANs and TAMs, as well as cancer stem cells, thereby favoring tumor progression [278,279]. This evidence concerns the gene CXCR1 and neoplasm.