In another study, Tau, α-tubulin, and βIII-tubulin were analyzed by immunohistochemical expressions in 183 primary breast carcinoma patients who had undergone surgical resection, and the results indicated that the loss of α-tubulin expression was significantly associated with lymph node metastasis and distant metastasis [88]. The gene discussed is MAPT; the disease is metastatic malignant neoplasm in the lymph nodes.