Recessive loss-of-function variants in the histidine triad nucleotide-binding protein 1 (HINT1) gene are associated with a common form of Charcot-Marie-Tooth (CMT), representing 2% of all CMT cases and about 10–12% of recessive CMTs [2], firstly described in 2012 [3]. This evidence concerns the gene HINT1 and Charcot-Marie-Tooth disease.