CDH1 and neoplasm: A recent review of published CDH1 mutations revealed 27 distinct germline CDH1 mutations, including c.760G>A (p.Asp254Asn) [3,4,8], that are linked to congenital syndromic and non-syndromic orofacial clefts without apparent susceptibility to tumor development, whereas eight further CDH1 mutations were associated with both HDGC and CL/P [5,9,10].