HepG2 was originally isolated from what was believed to be HCC in a 15-year-old Caucasian male [5], but Lopez-Terrada et al. found that HepG2 shares more characteristics with hepatoblastoma (HB) than with HCC, such as the loss of chromosome 4q [3], trisomies 2 and 20 [6], and a large deletion in exon 3 of the β-catenin (CTNNB1) gene [6,7]. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.