Moreover, we also identified RAB11FIP4, which enhances the metastatic potential of HCC in hypoxic conditions; OIT3, which is involved in liver development; HKDC1, a member of the hexokinase protein family involved in glucose homeostasis and hepatic lipid accumulation; and SERPINA1, an inhibitor of serine proteases associated with chronic liver disease. This evidence concerns the gene HKDC1 and hepatocellular carcinoma.