SLC3A2 and B-cell chronic lymphocytic leukemia: From a molecular perspective, CLL can be divided into two main subtypes depending on the mutational status of the immunoglobulin heavy-chain variable region gene (IGHV): IGHV-mutated (IGHV-M) and IGHV-unmutated (IGHV-UM) CLL, each exhibiting distinct genetic profiles and prognostic outcomes [4].