The final multivariate model further confirmed late-stage tumors (p = 0.0002; HR = 2.97; 95% CI 1.40–3.12) and HOXA7 overexpression (p = 0.024; HR = 1.58; 95% CI 1.06–2.35) as independent biomarkers of OS in ESCC (Table 4; Figure 3A). This evidence concerns the gene HOXA7 and esophageal squamous cell carcinoma.