In addition, somatotropinomas exhibit frequent variation in the expression of the following mRNAs: T-PIT, NF1, NR5A1 (SF1), PIT-1, PRKARIA, GPR101, DRD2, miRNAs associated with the long noncoding RNA MEG3 and miR532-let7 (miR-574, miR-195, miR-497-5p e let-7) cluster, and lncRNAs such as H19 and MEG3 that are differentially expressed as compared to normal tissue. Here, MEG3 is linked to growth hormone-producing pituitary gland neoplasm.