The findings of this study confirmed intergenic interactions of the SNPs GSTO1_rs4925, AGER_rs2070600, and ESR1_rs3844508 with variables such as age, MMSE evaluation of cognitive status, high triglycerides, and having HTA and T2M, showing a higher risk for susceptibility to dementia OR = 26.662 95% CI (16.164–43.979) with p < 0.001. Here, GSTO1 is linked to dementia.