Of 1600 hematologic malignancies sequenced over this time period, 1% (16/1600) were found to be BRAF-mutant, including the two AML cases (12.5%, 2/16) described here, as well as patients with HCL (62.5%, 10/16), chronic lymphocytic leukemia (12.5%, 2/16), a malignant histiocytic neoplasm (6.25%, 1/16), and multiple myeloma (6.25%, 1/16). Here, BRAF is linked to B-cell chronic lymphocytic leukemia.