BRAF V600E mutations are common in solid tumors, including melanoma and papillary thyroid cancer, and hematologic neoplasms, such as Langerhans cell histiocytosis (LCH) and hairy cell leukemia (HCL), but infrequent in myeloid malignancies [2]. The gene discussed is BRAF; the disease is hematopoietic and lymphoid system neoplasm.