Accordingly, the genomic landscape of MDS and MDS/MPNs includes mutations in genes affecting epigenetic regulation (TET2, DNMT3A), histone modification (ASXL1, EZH2), RNA splicing (SRSF2, SF3B1, U2AF1, ZRSR2), signal transduction (NRAS, KRAS, CBL, PTPN11, JAK2), and nucleosome assembly (SETBP1, RUNX1) [3]. The gene discussed is SF3B1; the disease is myelodysplastic syndrome.