EZH2 and myelodysplastic syndrome: Accordingly, the genomic landscape of MDS and MDS/MPNs includes mutations in genes affecting epigenetic regulation (TET2, DNMT3A), histone modification (ASXL1, EZH2), RNA splicing (SRSF2, SF3B1, U2AF1, ZRSR2), signal transduction (NRAS, KRAS, CBL, PTPN11, JAK2), and nucleosome assembly (SETBP1, RUNX1) [3].