Accordingly, the genomic landscape of MDS and MDS/MPNs includes mutations in genes affecting epigenetic regulation (TET2, DNMT3A), histone modification (ASXL1, EZH2), RNA splicing (SRSF2, SF3B1, U2AF1, ZRSR2), signal transduction (NRAS, KRAS, CBL, PTPN11, JAK2), and nucleosome assembly (SETBP1, RUNX1) [3]. Here, PTPN11 is linked to myelodysplastic syndrome.