Although the histiocytic and AML samples shared the BRAF V600E mutation with comparable VAFs, the AML possessed additional aberrations including somatic variants in KRAS, NRAS, EZH2, and IKZF1, RUNX1::POU2F2 fusion, and monosomy 7 [11]. The gene discussed is POU2F2; the disease is acute myeloid leukemia.