Most individuals of West African descent are homozygous for a single-nucleotide polymorphism (SNP) (T > C mutation at nucleotide −33) in the DARC or ACKR1 gene promoter region that disrupts a GATA-1 binding site, leading to erythroid-specific loss of expression of the Duffy antigen for chemokines (Duffy null) and protection from malaria [3]. This evidence concerns the gene ACKR1 and malaria.