For example, cognitive deficits have been observed in the presence of pathogenic variants in E2 and E3 encoding genes, as seen in Angelman syndrome (UBE3A) and intellectual disability (UBE2A, UBCl1, CUL4B, HUWE1, BRWD3) [15,16,17,18,19,20,21]. This evidence concerns the gene UBE2A and Intellectual disability.