SERAC1 and Encephalopathy: Variants in human SERAC1 are associated with a spectrum of disorders, including MEGDHEL syndrome (3-methylglutaconic aciduria with deafness–dystonia, hepatopathy, encephalopathy, and Leigh-like syndrome) [9,13,14,15], juvenile-onset complicated spastic paraplegia [16], and adult-onset generalized dystonia [9,17].