PNPLA3 and steatosis: However, the other polymorphisms were not significantly associated with the severity of steatosis: PNPLA3 GG vs. CC + CG genotypes (25.6% vs. 34.9%, p = 0.214), TM6SF2 CT + TT vs. CC genotypes (37.5% vs. 29.5%, p = 0.293), and SIRT5 GG vs. TT + TG genotypes (21.4% vs. 32.1%, p = 0.556) (Figure 1b).