EHMT2 and Prader-Willi syndrome: Non-integrative lentiviral constructs were designed encoding for the shRNA(hEHMT2/mEhmt2-11) and shRNA(hEHMT2/mEhmt2-14) targeting mouse Ehmt2 and human EHMT2 and were applied to mature iPSC-derived neurons from two different PWS patient cell lines (UPD and SD).