HK2 and hepatoblastoma: Key molecular drivers of the Warburg effect in hepatoblastoma include Hypoxia-Inducible Factor 1-α (HIF-1α), which, stabilized by hypoxia or Wnt/β-catenin signaling, promotes glycolysis by upregulating enzymes like hexokinase 2 (HK2), phosphofructokinase (PFK1), and pyruvate kinase M2 (PKM2).