Recently, Sheng et al. identified the presence of ferroptosis in the quadriceps muscle of cecum ligation- and puncture (CLP)-induced sepsis mice, as evidenced by increased expression of the ferroptosis marker proteins COX2, ACSL4, and ferritin heavy chain 1 (FTH1) and the downregulation of GPX4 expression. Here, GPX4 is linked to Sepsis.