Thus, abnormal Tau aggregation is a defining feature of tauopathies, including Alzheimer’s disease (AD) and corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), argyrophilic grain disease (AGD), globular glial tauopathy (GGT), and Pick’s disease (PD) [4,34]. The gene discussed is MAPT; the disease is Alzheimer disease.