MAPT and supranuclear palsy, progressive, 1: Thus, abnormal Tau aggregation is a defining feature of tauopathies, including Alzheimer’s disease (AD) and corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), argyrophilic grain disease (AGD), globular glial tauopathy (GGT), and Pick’s disease (PD) [4,34].