Thus, abnormal Tau aggregation is a defining feature of tauopathies, including Alzheimer’s disease (AD) and corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), argyrophilic grain disease (AGD), globular glial tauopathy (GGT), and Pick’s disease (PD) [4,34]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.