Disease-specific misfolded protein/s found in the brain include, for example, amyloid-beta (Aβ) and hyperphosphorylated Tau protein in Alzheimer’s disease (AD), α-synuclein in Parkinson’s disease (PD), multiple system atrophy (MSA), the prion protein (PrP) in prion diseases, and SOD1 in Lou Gehrig’s disease. This evidence concerns the gene MAPT and Parkinson disease.