These findings correlate with a previous report of differential expression of the percentage of T regulatory cells expressing SEMA3A in patients with active CD and active UC, which was significantly lower when compared to that of the healthy controls (p < 0.001 and p < 0.0001, respectively), where the authors suggest that this is partially responsible for their failure in preventing CD4+ effector T cell-induced inflammation in IBD in peripheral blood [16]. The gene discussed is CD4; the disease is inflammatory bowel disease.