By using human hepatoma Huh-7 or HepG2 cells treated with xanthohumol at 10 or 20 μM for 24 h, the authors observed, in both cell lines, a dose-dependent decrease in either ANGPTL3 mRNA expression (36% and 65%, respectively), protein expression (44% and 66%, respectively), or secreted ANGPTL3 proteins to the medium (34% and 47% lower), as compared to the control cells. The gene discussed is ANGPTL3; the disease is hepatocellular carcinoma.