NR2E1 and Cognitive impairment: The Tlx-OE mice showed better recovery than control mice in the rotarod test (Figure 3E), which suggests that the newborn neurons in the Tlx-OE mice were contributing to the coordination and motor functional recovery after stroke, agreeing with the findings of previous studies that Tlx overexpression improves behavioral score and cognitive deficits in rats and mice [11,21,23].