MYH11 and familial thoracic aortic aneurysm and aortic dissection: However, in our subsequent study, comprehensive multi-omics analysis revealed that genes involved in the elastin- unit were not affected by the K1256 deletion of Myh11, and several calcium channels, including Cacna1h, Trpm2, Hcn2, Hcn3, and Hcn4, were downregulated in the FTAAD model [7].