Previously, we developed a familial thoracic aortic aneurysm and aortic dissection (FTAAD) model by deleting K1256 of myosin heavy chain 11 (Myh11), which led to the development of aortic dissection upon stimulation with angiotensin II [6]. Here, MYH11 is linked to familial thoracic aortic aneurysm and aortic dissection.