There are several uncharacterized motifs of POLD3 that are important for maintaining genome stability and human health, mutations in those are associated with familial hearing impairment [11] and Omenn Syndrome [12].The significance of POLD3 in mammalian health is clear from the adverse effects on genome stability and fertility from deletions and knock-downs of POLD3 [13,14], and from Cancer Dependency mapping (DepMap [15]), and studies showing that it underpins hyperactive DNA synthesis in tumorigenesis [16,17] and spermatogenesis [18]. The gene discussed is POLD3; the disease is cancer.