RYR1 and muscle tissue disorder: Similar findings have been observed in muscular disorders, such as malignant hyperthermia and central core disease caused by mutations in genes encoding the following: (i) Ca2+ release channels (the ryanodine receptors, RYR), (ii) calsequestrin (CASQ), and (iii) the dihydropyridine receptor (CACNA1s), a voltage-dependent L-type Ca2+ channel located on the T-tubule [111].