Increased levels of other chemokines and cellular adhesion molecules, such as human macrophage chemoattractant protein-1 and E-selectin, along with additional pro-inflammatory cytokines and acute phase proteins, such as C-reactive protein (CRP), alpha-1-acid glycoprotein, and haptoglobin, have been identified in patients with depression. The gene discussed is CRP; the disease is major depressive disorder.