GPR55 and colorectal cancer: PLA2G3 is a sPLA2 that has been associated with the development of colorectal cancer by the production of pro-inflammatory metabolites, including several lysophospholipids, such as lysophosphatidic acid (LPA) and lysophosphatidylinositol (LPI) [57], which have been suggested to promote colon inflammation through the lysophosphatidic acid 2 (LPA2) and G protein-coupled receptor 55 receptors (GPR55), respectively [58,59].