CD8A and cancer: More recently, Ge and collaborators found that PLA2G2A mediates immune escape in pancreatic cancer through its effects on CD8+ T cells: PLA2G2A derived from cancer-associated fibroblasts reduces the secretion of IFN-γ and Granzyme B in CD8+ T cells, impairing their cytotoxic activity against tumor cells and facilitating the immune escape [98].