Different works demonstrate an association between phospholipases and Wnt signaling, β-catenin and the Wnt target gene EphB2, TGF-β and Phosphatidylinositol 3-kinase/Protein kinase B (PI3K/Akt) in different cancer tissues [65,66,67], all of them molecular pathways closely linked to tumor processes. This evidence concerns the gene EPHB2 and cancer.