They used an experimental model of acute retinal ischemia and analyzed the changes in retinal function and retinal morphology and showed that retinal ischemia induces Müller cell gliosis (which can include the release of proinflammatory cytokines such as TNF-α, an excess production of NO, and the triggering of direct or indirect cytotoxic effects), along with increased TRPM7 channels in Müller cells. This evidence concerns the gene TRPM7 and retinal ischemia.