The significant similarity in 3D structures, thermodynamic, and electric properties of the catalytic domains of hACE2 and rACE2 suggests that rabbits can be successfully used as an animal model for the investigation of both infectious and non-infectious diseases with involved ACE2, including the coronavirus infection, allowing the results to be extrapolated to humans, and also for the in vivo investigation of various agents that disrupt the interaction of ACE2 with the coronavirus S-protein, such as potential antiviral drugs. Here, PROS1 is linked to infectious disease.