CCL4 and osteoporosis: The positive effects of ICOS-Fc in tissue repair are also supported by the previous findings that the treatment with ICOS-Fc favors liver repair after the acute damage induced by CCL4 [18], counteracts organ injury in sepsis [23], and protects from the development of osteoporosis [12], which opens the way to exploit ICOS-Fc as a powerful immunoregulatory tool to improve tissue repair in different contexts of tissue injury.