Corroborated with the above viewpoint, in AGD subjects, cytoplasmic TDP-43 aggregates tend to be prominent in cases with severe grain pathology, while the co-localization of p-TDP-43 and p-Tau has been observed only in part of the NCIs, suggesting that the abnormal aggregation of TDP-43 may be involved in the pathological process and disease progression of AGD [195]. This evidence concerns the gene MAPT and argyrophilic grain disease.