MAPT and amyotrophic lateral sclerosis: With experimental evidence, TDP-43 oligomers can cross-seed the soluble Aβ or Tau to form Aβ/Tau oligomers via the co-aggregation capacity of TDP-43 with Aβ or Tau [88,173]; while the TDP-43 oligomers are also found to accelerate Tau aggregation and co-localize with Tau in the post-mortem brains of ALS and FTD [88].