ATXN2 and amyotrophic lateral sclerosis: A recent study has revealed that the intermediate polyQ (33Q) Atx2 can cause motor deficits, neuromuscular junction changes and Purkinje cell degeneration, and can trigger robust transcriptomic changes through its interaction with the mutant TDP-43 (M337V) [258], indicating that Atx2 intermediate expansions can uncover and exacerbate several ALS-relevant phenotypes in a mutant TDP-43 ALS background.