As mentioned above, TDP-43 aggregates can also be detected in synucleinopathy-related diseases, such as PD with or without dementia [197,198,199,322], dementia with Lewy bodies (DLB) [197,200,201,289] and multiple-system atrophy (MSA) [202,203], in which the pathological signature inclusions are mainly composed of α-Syn. Here, TARDBP is linked to multiple system atrophy.