Similarly, in ischemic stroke models, downregulation of miR-199a-5p has been demonstrated to protect neurons against apoptosis and enhance cell viability through the CAV-1/MEK/ERK axis [52], while also improving cognitive function and reducing neuronal apoptosis in the hippocampus via activation of the AKT signaling pathway [53]. This evidence concerns the gene AKT1 and ischemic stroke.