In MPTP mouse models, a face validity model that replicates the PD phenotype in humans [7,8,22], AAV(serotype 2)-mediated overexpression of Nurr1 and its co-transcription factor, Foxa2, in the midbrain, produced substantial neuronal recovery and caused a decrease in pro-inflammatory cytokines [22]. The gene discussed is FOXA2; the disease is Parkinson disease.