In a 6-OHDA rat model, CDNF injections significantly reduced the degeneration of DAnergic neurons [67], and a brain-penetrating peptidomimetic compound based on human CDNF, called HER-096, also protected DAnergic neurons and reduced synuclein-aggregation and inflammation in a mouse synucleinopathy model of PD [68]. Here, CDNF is linked to synucleinopathy.