Moreover, an early-onset of autolysosomal pathology has been identified in the polyglutamine disease dentatorubral-pallidoluysian atrophy (DRPLA), in which canonical autophagy is chronically inhibited and eventually activates the alternative autophagy pathways, including the GOMED and nucleophagy-mediated degradation or secretion of LMNB1. This evidence concerns the gene LMNB1 and dentatorubral-pallidoluysian atrophy.