MAPT and neuroblastoma: The link between tau acetylation and hyperphosphorylation has been shown in the human neuroblastoma cell line SH-SY5Y overexpressing acetyltransferase p300, which acetylates tau at K280 causing its phosphorylation on S199, AT8 (S202, T205), AT180 (T231), S262, and S422 [45] and accumulation.