POU2F2 and cancer: In silico analysis indicated that POU2F2, a transcription factor in the POU family, plays significant roles in cancer progression and development, as well as in melanocyte development and CM progression, as it responds to MAPK pathway activation and modulates melanocyte-inducing transcription factor (MITF) levels, suppressing the differentiated melanocytic phenotype and enhancing tumor metastasis [21].