Palacios et al. (2008) [16] identified higher expression of CTLA-4 in patients with multiple sclerosis and the AA genotype of the c.-1577G>A SNV and association of the CTLA-4 c.-1577AA genotype, and increased risk of acute lymphoblastic leukemia was also observed by Aref et al. (2023) [17]. Here, CTLA4 is linked to multiple sclerosis.