In univariate Cox analysis, all these factors were predictors of MSS; patients older than 54 years, with non-superficial tumors, tumors of Clark level III–V, stage III or IV, and CTLA-4 c.-1577 AA genotype had 2.33-, 5.56-, 5.94-, 3.78-, and 1.60-times more chances of dying by tumor relapse, progression, or effects than others, respectively. This evidence concerns the gene CTLA4 and neoplasm.