The direct interactions of rutin, beta-sitosterol, quercetin, norisoboldine, and hyperoside with key disease-related proteins such as TGFB1, TNF, IL1B, IL6, and CAT suggested that these compounds may modulate critical pathways involved in the pathology of postmenopausal osteoporosis. This evidence concerns the gene TGFB1 and postmenopausal osteoporosis.