ACE2 and infection: Natural and modified ACE2-derived polypeptides [28,29,30,31], corresponding to the entire receptor ectodomain [32,33] in a monomeric (Ig-Fc-fused) or artificially multimerized form as well as to specific ACE2 fragments [31], have been shown to act as virus sequestering decoys and to inhibit infection by several SARS-CoV-2 lineages [33,34,35,36,37].