Vascular disturbances in AD may result from the down-regulated expression of both the mesenchyme homeobox 2 (MEOX2), a homeodomain transcription factor associated with angiogenesis and smooth muscle cell migration, and the lipoprotein receptor-related protein (LRP), a crucial molecule for Aβ clearance, in endothelial cells. This evidence concerns the gene MEOX2 and Alzheimer disease.