APP and early-onset autosomal dominant Alzheimer disease: Therefore, in the context of Alzheimer’s disease research, particularly in the mouse model APP/PS1, the inhibition of the mammalian target of rapamycin (mTOR) signaling through the PTEN/PI3K/Akt pathway has been identified as a facilitator of the autophagic degradation of amyloid-beta, also associated with improved cognitive function [159,160].