In vivo, increased WNT/β-catenin signaling leads to the expression of the pro-inflammatory cytokines IL-1β and IL-6 in alveolar epithelial type cells in the bleomycin model, and it provides a WNT/interleukin axis link in the development of pulmonary fibrosis [66,67]. The gene discussed is IL6; the disease is pulmonary fibrosis.