CCN4 and idiopathic pulmonary fibrosis: Results showed 0.25 and 0.5 U/kg bleomycin increased expression levels of (pro-) fibrotic cytokines, which are the mediators involved in the activation of the myofibroblast during fibrogenesis (TGF-β1, IL-13, IL-6, WISP-1, and VEGF), angiogenesis (VEGF), matrix remodeling (TIMP-1), and biomarker of lung function (CRP) in a mouse model of IPF, which are consistent with previous reports using 1.5–3 U/kg bleomycin [7,8,12,44,45,46,47].