ISL1 and Alzheimer disease: Table 4 shows the top 10 mRNAs associated with ADAOO in our sample. Interestingly, ENST00000257696 (β^=4.34; HILPDA) and ENST00000304060 (β^=4.79; ZNF440) delay ADAOO, whereas ENST00000263851 (β^=−17.31; IL7), ENST00000340552 (β^=−12.6; LIMK2), and ENST00000230658 (β^=11.05; ISL1) are the top accelerators. However, only ENST00000340552 (LIMK2), which accelerates AD onset by ~12.6 years (Table 4) showed a statistically significant association with ADAOO after FDR correction.