In multivariate analysis risk, symptoms of overall leukopenia were conditioned by two genetic factors: ABCC1 gene rs129081 allele G (OR 1.89; 0.27–0.99; p = 0.048) and DPYD rs291593 allele T (OR 1.73; 1.08–2.76; p = 0.020) (Table 2). This evidence concerns the gene DPYD and Decreased total leukocyte count.