AKR1C3 and breast carcinoma: In the study of Liu et al. [35], it was not associated with the risk of childhood leukemia; similarly, the group of Voon reported a lack of correlation between AKR1C3 rs3209896 genotype AG, survival time (PFS and OS), and chemotoxicity in breast cancer patients treated with doxorubicin-containing chemotherapy [38].