Based on the promising results of our previous studies regarding mTOR kinase inhibitors in inhibiting proliferation, the cell cycle, tumor invasion [14,15], and activation of the apoptosis process in melanoma cells [16,17], we decided to test different concentrations of everolimus in combination with chloroquine on caspase-3 activation, apoptosis, proliferation, and organization of cellular structures and lipid redistribution. Here, CASP3 is linked to melanoma.