CASP3 and melanoma: A similar increase in caspase-3 activation was observed for a much higher concentration—10 μM of everolimus—in melanoma cell lines derived from metastases Me15392 and MEWO (p < 0.001), while for the primary melanoma cell line—WM3211—these values did not exceed 8 times that of the control (Figure 2A, Figure 3A and Figure 4A).