In the renal tissues of LN patients, the expression of YY1 was significantly elevated in both renal tubules and glomeruli, as shown in Figure 3D. A similar upregulation of YY1 at both the mRNA (Figure 3G) and protein levels (Figure 3E,F) was also observed in the kidneys of mice with LN compared to control mice. This evidence concerns the gene YY1 and lobular neoplasia.