In a Gba1-prone mouse model of (Gba1 9V/−) and conduritol B epoxide (CBE)-mediated glucocerebrosidase-targeted experimental mouse model of Gaucher disease, we have shown an increased recruitment of CR3-expressing macrophages and dendritic cells to tissues including the liver, spleen, and lungs. The gene discussed is GBA1; the disease is Gaucher disease.