PECAM1 and Fabry disease: Furthermore, patients with Fabry disease exhibit elevated blood lymphocyte counts, increased levels of specific T cytotoxic cell subsets (CCR4+CXCR3+ and CCR6+), higher numbers of MHCII+ CD1d+ CD11b+ CD31+ monocytes, and notable tissue infiltration by macrophages and B cells [11,78,80,81,82,83,84,85,86].