C3 and Fabry disease: Research has consistently demonstrated elevated levels of complement components, including complement 1q subcomponent c (C1qc), C3, inactivated C3b (iC3b), C4, and complement factor B (CFB), alongside the production of complement fragments C3a and C5a, in serum, plasma, and tissue samples from both animal models and human patients with Fabry disease (Table 1).