Patients with Fabry disease also demonstrate an increase in T cell subsets and increased circulatory levels of pro-inflammatory cytokines, such as TNFα [12,77,79,82,460,461,462], IFNγ [82], IL1α [460], IL1β [12,77,460], IL6 [21,79,461,462], and IL17 [21]. This evidence concerns the gene IL1A and Fabry disease.