A C3aRA-treated mouse model of middle cerebral artery occlusion showed lower expression of ICAM1 on endothelial cells, decreased neutrophil infiltration in the ischemic zone, and smaller stroke volumes compared to vehicle-treated controls, suggesting that targeting C3aR effectively modulates stroke-related injury in ischemia/reperfusion scenarios [325]. The gene discussed is ICAM1; the disease is stroke disorder.