Notably, many of these immune cells, such as monocytes, macrophages, and T and B cells express C3aR and C5aR1, highlighting their potential migration towards the tissue expressing the potent chemoattractants C3a and C5a that process the tissue damage in patients with Fabry disease [99,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,125,126,127,128,129,130,131,132,133,134]. The gene discussed is C5AR1; the disease is Fabry disease.