Produced by macrophages, IL-6 impairs the cytotoxic function of NK cells [50], with an innate and adaptive pro-inflammatory effect [25].IL-8 recruits neutrophils which produce IL 17A, VEGF, and cyst formation [51];IL-19 and IL-22 are immunosuppressive and anti-inflammatory; IL-19 promotes Th2 cells, increasing the expression of IL-10 [25]. This evidence concerns the gene IL10 and cyst.